subtitle playback
This is still a little weird. I found that the web client (in a browser) handles this really well with default settings. However, if I try to use the desktop app or a mobile client, I have to force it to burn in the subtitles for them to show up reliably. Fortunately, there are per-client settings for this now:
It’s been a while since I last used LaTeX since I am in industry now, but there is definitely a learning curve. If you are talking about undergrads, then it might be too steep a challenge for most to want to take on unless they plan on pursuing academia long-term. Like others have mentioned, LaTeX is a kind of standard that you see used a lot in academic circles. Some journals also like or support things that are created through tex and will have their own templates to use.
Basically, LaTeX consists of writing in a markup language, like your screenshot, and then running that through a processor that interprets your .tex file and creates the formatted output (usually a pdf). Back in my day, TexnicCenter was the program of choice to write the actual .tex file, but some quick searching and it looks like VSCode with an appropriate extension is probably one of the best/easiest ways to do it now.
The most annoying part of tex is references. I remember being utterly confused by BibTeX when I was trying to get it to work. I am way out of date on what best practices for today might be, but I hope they have improved that process somewhat.
Seconding LaTeX as the gold standard for formatting math/science in written form. Some of my peers in grad school (physics) wrote up their assignments in it (I opted instead for massive reams of handwritten work). However, I did write up my thesis in LaTeX. My university had a LaTeX template for a thesis that took care of the boilerplate formatting, I just had to focus on the content.
I own a Prius (not a PHEV though, just a hybrid) and can corroborate that my mileage goes down significantly in the winter months. It is a combination of a couple factors in my experience.
I tend to average ~45 mpg in the summer and ~37 mpg in the winter over the past two years.
Starting a new community is an uphill slog. Some tips and observations:
Fantastic, thanks! I haven’t made announcements yet about the new community, but hoping to do that some time this week when I get a chance.
I haven’t been able to post as much this past week compared to normal, but things have been going ok:
The not as active ones:
You must have taken Nokotan’s loss pretty hard. /s
Good luck finding new mods and I am hoping that you are able to come back before Dan Da Dan season 2 this summer.
Recently, in !anime@ani.social, I configured the episode discussion bot to create posts using the poster art of the show rather than just an empty discussion post as a bit of an experiment about the effect of images. I don’t have hard analytics to dig into, but I have noticed that the episode discussion threads have garnered significantly more votes when they have images, and a small increase in comments. Though, the additional comments are usually just wandering folks instead of people that stick around and engage.
I still don’t let fanart in either the main anime nor manga community because it would too quickly spiral out of control. There is simply too much fanart in existence for these things. Instead, I limit it to official art only, which usually means teasers/posters/trailers. In the manga community, there is a bit of a special case in that I do allow fanart of a series if it was done by a different published author (not just some random pixiv user). This happens sometimes when a series ends and you get other authors drawing commemorative art for it.
I work in pharma, regularly writing and filing things with the FDA (and other agencies), and this has been a topic of conversation at work. The good news for people is that the EMA is still a thing in the EU. So, at least the large pharma companies (like the one I work for), are likely to not really change much about their quality control/processes/etc. because we will still need to conform to the EMA guidelines which are typically in line with the current FDA (sometimes more strict, sometimes less so). The real quality concern would be smaller companies that only file for products in the US. They would only need to meet whatever new FDA guidelines come into effect (if they even do, changing stuff like GMP guidance is extremely complicated and time consuming) since the US is their only market.
The products I work on are mostly monoclonal antibodies (and the occasional gene therapy product mixed in). So, the types of diseases they are used to treat vary. To be honest, I work on the process/formulation side of the development pipleline and the actual clinical treatment part is pretty much inconsequential to what I do. Some of the past programs I have worked on include treatments for asthma, eczema, multiple myeloma, breast cancer, MS, hemophilia, and tons of others that I don’t remember. Often, when dealing with antibodies, the same medicine can be effective for multiple indications.
The finished vials, post-lyophilization, sealing, labeling, and packaging, are sent to infusion clinics. There, clinicians will add water to the vials to reconstitute the drugs and then administer them to patients via IV (usually).
Watching TC do a video about something I do professionally has been a bit of a trip. For context, I work with freeze dryers (we call them lyophilizers) in pharmaceuticals rather than foods. I help design the lyophilization cycles for biologics and gene therapy products that get preserved through freeze drying. Until this video, I had no idea that people used these instruments for at-home food preservation (which is kind of insane imo).
The instruments that I work with are typically a much larger version of the bench-scale machine that he is using (usually one of the LyoStar line). However, I have used smaller, bench-scale units as well for some quick and dirty work. I included some pictures at the end behind a spoiler tag. Happy to answer any questions people have.
Some differences in how I use lyophilizers in a scientific setting as opposed to a home-use food setting:
Benchtop lyophilizer that I have experience using. You can see some vials lined up inside the door. I have never used the bottle connections hanging off the side:
One of the trays of vials that is loaded before going into the lyophilizer. The vials that are partially stoppered in the middle of the tray actually contain the drug. All the vials without stoppers are empty and simply there to help hold things in place as well as distribute heat predictably through the tray. The stoppered vials in the corners are there to help distribute the weight as the shelves compress to fully seat the stoppers.
Here are a small number of vials that I ran on a benchtop unit without any spacer vials or the tray. I would never do this for any reason other than to take a picture like this. This is a good view of what a partially stoppered vial looks like. It allows a path for water vapor to escape out the top of the vial.
Finally, here is a vial post-lyophilization. The liquid has turned into a solid, white cake at the bottom of the vial. This is because most lyophilization formulations include sugars that provide structure for the cake and keep it porous. The sugars provide protection against freeze/thaw stress for the molecule of interest as well. The porosity of the cake allows for quick and easy reconstitution by adding water, usually in <30 seconds or so.
I think that user donations are easier when an instance has a good focus. There are some other instances I can think of where the donation model has been enough to cover things. In addition to feddit.dk and beehaw, an instance I use most of the time, ani.social, is more than covered by donations last I checked. It looks like @hitagi@ani.social even took away the donate link in the sidebar. Never mind, I am just blind. I didn’t notice the little Ko-fi badge at the bottom. I was looking for a text link.
There is a lot of collaboration between the different instance admins in this regard. The lemmy.world admins have a matrix room that is chock full of other instance admins where they share bots that they find to help do things like find similar posters and set up filters to block things like spammy urls. The nice thing about it all is that I am not an admin, but because it is a public room, anybody can sit in there and see the discussion in real time. Compare that to corporate social media like reddit or facebook where there is zero transparency.
I think that @SJ_Zero@lemmy.fbxl.net was referring to the fact that a large portion of Musk’s net worth is tied to the Tesla stock price. The age of easy money that the US economy has been living in for most of the past 15 years has led to many stocks to greatly explode in value much farther beyond what makes sense at a fundamentals level; Tesla being one of the most egregious examples.
Not sure if I should dive into My Happy Marriage or not. From the synopsis, it almost sounds like a courtly love kind of thing, but I have seen some good reviews, so I might give it a shot if it keeps being well received. It could fill the Raeliana-sized hole left after last season.
Having more fun with this show than I thought I would. It knows that the premise is dumb, so it doesn’t waste time explaining things, just pulls out some blessing ex machina and moves on. I can see it growing stale as the season goes, but so far it’s fine for what it wants to be.
Also, poor Lammis. They made her carry our protagonist rather than stick him on the wagon.
Just for some background information on how most countries tend to rely on larger, more rigorous regulatory bodies…
I am in the pharma industry (not in vaccines though). Typically the two main regulators that most other countries look to as a reference are either the FDA or the EMA (the EU organization). This usually means that if you can satisfy the requirements of one of these bodies, then it is satisfactory for the other country as well. However, it isn’t universal as each other country will usually have some modifications here and there for whatever reason. The most annoyingly particular ones I have dealt with in the past are China and Japan.